Fatigue, Pain, Tingling, Weakness of Grip, Loss of Dexterity, Stiffness, Cramping, Numbness, Cold, Burning. They may often occur during or after periods of rest or sleep. In advanced cases, you may feel pain or cramping around the base of the thumb or your thumb may become nonfunctional.These symptoms often characterize the common disorder. By the time you feel any of them in your hand, wrist or arm, cell degeneration is in process and should be taken seriously. It often progresses rapidly if ignored and doesn't take years to develop as many think. Often, just a few mild instances suddenly never go away or are brought on by ever decreasing effort.
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